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Being such a large scale overhaul, Transcendence is going to be incompatible with other gameplay overhauls. Many mods like likely need patching due to the sheer scope of things. Even mods that don't directly conflict will likely need some sort of consistency patching, such as altering the values of items or de-leveling NPCs/leveled lists. I HIGHLY recommend playing with a relatively light load order with this mod, as with Requiem. This mod has a very delicate balance and could easily be disrupted by combining with other gameplay mods, such as bullet time or sprint. Please give this mod a try on its own before adding anything else!
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Alternate Start with Delayed Main Quest - HIGHLY recommended, a patch is provided.
Permadeath - Not necessarily a mod, but a playstyle I highly recommend trying - especially with alternate start!
The Living Desert - Game feels way too empty without this mod, a patch is provided.
Goodies - For all your uncut content needs, a patch is provided.
Essential DLC Enhancements Merged - Great collection of features that pair well with Transcendence, a patch is provided.
Essential Vanilla Enhancements Merged - Great collection of features that pair well with Transcendence, a patch is provided.
B42 Recoil, or your choice of recoil mod - This mod is balanced around some form of recoil mod, highly recommended. No patch needed for any recoil mod.
Radiant Infinium - Endless Questing Framework - A great roleplay mod and a good way to earn caps/XP early on. No patch needed.
Simple Currencies - Great economy/immersion mod, patch provided.
Fatigue Overhaul + FatigueHUD - Adds great alternative playstyle type, patch provided.
Simple Player Home Crafting Stations - No patch needed.
Mojave Scenery Overhaul - Just a great mod, but as far as synergy with this mod, it adds effects to all muck pools that pair well with this mod's radiation changes. No patch needed.